Saturday, March 5, 2011

What are the chances of an affected individual passing CLS to his or her children?

As I stated before, CLS follows an X-linked dominant inheritance pattern. Here are several scenarios:
If an unaffected male (XY) has children with a heterozygous female (X`X), half of their girls and half of their boys will have CLS. The affected girls will be heterozygous, and may or may not display CLS.
If an unaffected male (XY) has children with a homozygous affected female (X`X`), all boys will have CLS and all girls will be heterozygous and may or may not display the disorder.
If an affected male (X`Y) has children with an unaffected female, all daughters will be heterozygous for CLS, while all sons will remain unaffected.
To repeat what I said before, however, most cases (70-80 percent) occur from spontaneous mutations on the X-chromosome, not from inheritance.

No comments:

Post a Comment